Microfluidic culture prior to islet transplantation These studies explore the unique properties of microfluidic flow to prepare islets prior to transplantation for the treatment of Type 1 Diabetes.
Microfluidic devices to measure nanoparticle tissue interaction Nanoparticles 10-100 nm in diameter show promise as theragnostic agents for Type 1 and 2 diabetes, and cancer. We are exploring the interaction of these particles with pancreatic islets using microfluidic flow.
Mechanisms of FGFR1/KLB receptor activity FGF21 analogues for the treatment of Type 2 diabetes act through FGFR1/KLB in islets, liver, and white adipose tissue. We are exploring receptor dynamics focusing on regulation by the galectin lattice.
Measuring the dynamics of islet metabolism Beta-cell metabolic flux is a critical trigger of insulin secretion and integral to type 2 diabetes. We measure islet metabolic flux with high spatial and temporal resolution using two-photon and confocal autofluorescence and metabolic sensor imaging.